One layout that worked well for the majority is the large rectangle (336X280). Why choose this format out of the many you can use? On the whole because the ads will look like regular web links, and people, being used to clicking on them, click these types of links.

Construct a custom palette for your advertising. Choose a colour that will go well with the background of your site. If your site has a white background, attempt to use white as the colour of your ad border and background. The idea to patterning the colours is to make the adsense look like it is part of the web pages. This will result to more clicks from people visiting your site.  Read the full story